Benefits of Zmax

The advantage of taking Zmax (azithromycin extended release) is that while other antibiotics can require 7 to 10 days of treatment, Zmax delivers a complete course of treatment in a single dose. So with Zmax you never have to worry about forgetting to take your medicine or missing a dose.^1-3

Next: Is Zmax Right for You?

Next: Is Zmax Right for You?

Zmax is indicated for mild to moderate acute bacterial sinusitis in adults due to Haemophilus influenzae, Moraxella catarrhalis, or Streptococcus pneumoniae and is also indicated for community-acquired pneumonia due to Chlamydophila pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae, or Streptococcus pneumoniae in adult and pediatric patients aged 6 months and over, deemed appropriate for oral therapy.

Zmax is contraindicated in patients with known hypersensitivity to azithromycin, erythromycin, or any macrolide or ketolide antibiotic. If an allergic reaction occurs, appropriate therapy should be instituted. Physicians should be aware that reappearance of the allergic symptoms may occur when symptomatic therapy is discontinued.

There have been rare reports of serious allergic reactions including angioedema, anaphylaxis, Stevens Johnson syndrome and toxic epidermal necrolysis in patients on other formulations of azithromycin therapy. Rarely, fatalities have been reported.

Clostridium difficile associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including azithromycin, and may range in severity from mild diarrhea to fatal colitis. CDAD must be considered in all patients who present with diarrhea following antibiotic use. Careful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents. If CDAD is suspected or confirmed, ongoing antibiotic use not directed against C. difficile may need to be discontinued, and appropriate management and treatment of C. difficile should be instituted as clinically indicated.

As with all macrolides, including Zmax, exacerbations of myasthenia gravis have been reported.

A higher incidence of gastrointestinal adverse events (8 of 19 subjects) was observed when Zmax was administered to a limited number of subjects with GFR <10 mL/min. Overall, the most common treatment-related adverse reactions in:

• Adult patients receiving a single 2-g dose of Zmax were diarrhea/loose stools (12%), nausea (4%), abdominal pain (3%), headache (1%), and vomiting (1%).
• Pediatric patients receiving the recommended Zmax dose of 1 mL/lb were vomiting (11.9%), diarrhea (8%), loose stools (5.6%), abdominal pain (3%), rash (2.8%), nausea (1.7%), and anorexia (1.2%).

Please see full prescribing information for Zmax.

The product information provided in this site is intended only for residents of the United States. The products discussed herein may have different product labeling in different countries.

The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider. All decisions regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient.

References